目的 探讨消旋卡多曲联合西咪替丁治疗小儿轮状病毒肠炎的临床疗效.方法 选取2014年5月至2015年5月期间在我院儿科住院治疗的76例轮状病毒肠炎患儿,按随机数表法随机分为两组,每组各38例,对照组予抗病毒等常规治疗,观察组在此基础上联合应用消旋卡多曲及西咪替丁治疗,比较两组患儿的临床疗效.结果 观察患儿在用药后平均退热时间、平均止吐时间、平均止泻时间及总病程均明显短于对照组[(1.68±0.73)d vs(2.14±0.75)d,(1.77±0.56)d vs(2.22±0.68)d、(2.42±1.47)d vs(3.98±1.79)d、(4.98±2.24)d vs(6.31±2.37)d],差异均有统计学意义(P<0.05);观察组患儿治疗总有效率为94.74%(36/38),明显高于对照组的78.95%(30/38),差异有统计学意义(P<0.05).结论 常规治疗的基础上联合应用消旋卡多曲及西咪替丁可使患儿发热、呕吐、腹泻等临床症状获得快速缓解,缩短病程,提高临床疗效.%Objective To investigate the clinical efficacy of racecadotril combined with cimetidine in the treat-ment of children with rotavirus enteritis. Methods Seventy-six children with rotavirus enteritis treated in Department of Paediatrics in our hospital from May 2014 to May 2015 were selected and randomly divided into two groups, with 38 patients in each group. The control group was given conventional antiviral treatment, while the observation group ap-plied racecadotril and cimetidine on the basis of the control group. The clinical efficacy was compared between the two groups. Results After treatment, the defervescence time, antiemetic time, antidiarrheal time and total disease course in the observation group were significantly shorter than those in the control group [(1.68 ± 0.73) d vs (2.14 ± 0.75) d, (1.77±0.56) d vs (2.22±0.68) d, (2.42±1.47) d vs (3.98±1.79) d, (4.98±2.24) d vs (6.31±2.37) d] (P<0.05). The effective rate of the observation group was significantly higher than that of the control group [(94.74%(36/38) vs 78.95%(30/38), P<0.05]. Conclusion Applying racecadotril and cimetidine on the basis of conventional therapy can relieve symptoms of fever, vomiting, diarrhea, shorten the course of disease, and improve the clinical efficacy.
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