双歧三联活菌胶囊治疗溃疡性结肠炎的疗效及其对CD4+CD25+调节性T细胞和IL-10的影响

摘要

目的 探讨双歧三联活菌胶囊辅助治疗溃疡性结肠炎(UC)的临床疗效及其对CD4+CD25+调节性T细胞和IL-10的影响.方法 选取溃疡性结肠炎患者87例,采用随机数表法分为观察组45例和对照组42例.对照组给予抗生素及5-氨基水杨酸制剂奥沙拉嗪钠胶囊进行常规对症治疗,观察组在常规对症治疗基础上加用双歧三联活菌胶囊治疗.比较两组患者治疗前后的结肠炎症评分、CD4+CD25+调节性T细胞和IL-10变化及临床疗效.结果 治疗后观察组的总有效率为86.67%,明显高于对照组的69.05%,差异有统计学意义(P<0.05);治疗前两组结肠症状评分比较差异无统计学意义(P>0.05),治疗后观察组结肠症状评分明显低于对照组,差异有显著统计学意义(P<0.01);治疗前两组CD4+CD25+调节T细胞占CD4+T细胞比例及IL-10水平值比较差异均无统计学意义(P>0.05),治疗后观察组CD4+CD25+调节T细胞占CD4+T细胞比例及IL-10水平均明显高于对照组,差异均有显著统计学意义(P<0.01).结论 歧乳杆菌三联活菌胶囊辅助治疗UC患者疗效确切,且CD4+CD25+调节性T细胞比例及IL-10水平均有明显升高,在改善患者肠道内微生物平衡中具有显著作用,值得推广应用.%Objective To investigate the clinical efficacy of bifidobacteria triple viable capsule and its effects on the levels of CD4+CD25+regulatory T cells and IL-10 in patients with ulcerative colitis (UC). Methods Eighty-seven patients with UC were randomly divided into observation group (45 cases) and control group (42 cases). The control group applied antibiotics and 5-amino salicylic acid for symptomatic treatment, and the observation group was treated with bifidobacte-ria triple viable capsule based on the control group. The colitis score, CD4+CD25+regulatory T cells and IL-10 changes before and after treatment were compared between the two groups. Results The total effective rate of the observation group was 86.67%, significantly higher than 69.05%of the control group (P<0.05). The colitis scores had no statistically significant difference between the two groups before treatment (P>0.05), but the scores in the observation group were significantly lower than those in the control group after treatment (P<0.01). The ratio of CD4+CD25+regulatory T cells to the total CD4+T cells and IL-10 levels had no statistically significant difference between the two groups before treat-ment (P>0.05), but they were significantly higher in the observation group than the control group after treatment (P<0.01). Conclusion Bifidobacteria triple viable capsule has significant clinical efficacy in the treatment of UC. It can significantly increase the ratio of CD4+CD25+regulatory T cells to the total CD4+T cells and IL-10 levels and improve the intestinal microbial balance, which is thus worthy of application and popularization.