高迁移率族蛋白B1在神经系统疾病中的研究进展

摘要

高迁移率族蛋白B1是一种在哺乳动物中广泛表达的非组蛋白染色体结合蛋白,并通过晚期糖基化终产物受体和TOLL样受体参与炎症反应过程,而大多数神经系统疾病的发病机制与自身免疫或免疫炎性损伤相关.本文就高迁移率族蛋白B1在神经系统疾病中的研究进展进行综述.%High mobility group box-1 (HMGB1) is widely expressed in mammalian with a non-histone chromo-somal binding protein, which is involved in the process of inflammatory by the receptors of advanced glycation end prod-ucts and Toll-like receptors, while the most of the nervous system diseases are related to autoimmunity or immune in-flammation injury. This article reviews the research progress of HMGB1 in the pathogenesis of nervous system diseases.