Twist基因在口腔鳞状细胞癌中的研究进展

摘要

Twist is an evolutionarily highly conserved II class of basic helix loop helix (basic Helix-Loop-He-lix, bHLH) transcription factors. It affects the cell apoptosis and is involved in epithelial mesenchymal transition, which has an important effect on the invasion, metastasis and drug resistance of tumor. Oral squamous cell carcinoma is the most common type of oral cancer, and its postoperative recurrence and metastasis often results in poor prognosis. This paper mainly summarizes the role of Twist gene in the occurrence and development of oral squamous cell carcinoma, covering aspects of tumor stem cells, epithelial mesenchymal transition, drug resistance, as well as tumor invasion and metastasis, in order to provide reference for diagnosis and treatment of oral squamous cell carcinoma and scientific re-search in the future.%Twist是一个进化上高度保守的II类碱性螺旋-环-螺旋(bHLH)转录因子,它影响细胞的凋亡、参与上皮-间质转转化(EMT)、对肿瘤的侵袭转移和耐药有重要的影响.口腔鳞状细胞癌(OSCC)是最常见的口腔恶性肿瘤,术后复发和转移导致口腔鳞状细胞癌患者预后较差.根据Twist基因在口腔鳞状细胞癌发生发展过程中的作用,从肿瘤干细胞、上皮间质转化、肿瘤耐药和肿瘤的侵袭转移等方面作一综述,为今后口腔鳞状细胞癌的诊断、治疗与科学研究提供新的方向与指导.