随着经济社会的不断发展，社会老龄化趋势日益加剧，与年龄相关的神经系统退行性疾病的发病也随之增加。而在这其中，阿尔茨海默症(AD)与帕金森病(PD)是最经典的两种神经系统退行性疾病，AD主要表现为进行性记忆功能减退和认知功能障碍；而PD主要表现为运动功能障碍，这两种疾病影响着全世界范围内约5000万的人口，而这其中大部分病例的分布特点表现为散发。研究表明AD及PD发病分别与Tau蛋白及α-突触核蛋白的关系密切，本文就Tau蛋白与α-突触核蛋白在这两种神经系统退行性疾病中的发病机制及两种蛋白的相关性加以综述。%Along with the continuous development of social economy and the aging of populations, the onset of age-related neurodegenerative diseases is increasing. Alzheimer's disease (AD) and Parkinson's disease (PD) are among the most classic neurodegenerative diseases. AD is mainly characterized by memory function impairment and cognitive dysfunction, and PD manifests mainly motor impairment. The two diseases affect about 50 million people in the world, and the cases are sporadic. Studies have shown that the pathogenesis of AD and PD is closely related to tau protein andα-synuclein. The review summarizes the pathogenesis of tau protein andα-synuclein in the two diseases and the correla-tion between the two proteins.
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