compound, pharmaceutical composition, method for treating a neurodegenerative disease, method for reducing the concentration of p-ser-alpha synuclein in brain tissue, and method for treating cancer

摘要

pteridinones as polo-like kinase inhibitors. The present invention provides compounds having a structure according to formula (I) or a salt or solvate thereof, wherein the ring a, x, r ^ 1 ^, r ^ 2 ^, r ^ 3 ^, r ^ 4 ^, r ^ 5 ^ and ^ 6 ^ are defined here. The invention further provides pharmaceutical compositions including the compounds of the invention and methods of making use of the compounds and compositions of the invention, for example in the treatment and prevention of various disorders, such as parkinson's disease.