儿童过敏性紫癜复发的危险因素分析

摘要

Objective To observe the prognosis of the children with Henoch-Schonlein purpura (HSP) and analyzethe cause of recurrence risk factors, and provide the basis for clinical intervention and prevention. Methods Theclinical data of 78 children with Henoch-Schonlein purpura (including outpatient visits and hospitalization), who admittedto the People's Hospital of Yangjiang City from May 2014 to May 2016, were collected and divided into the recurrencegroup and the non-recurrence group after 1 year of follow-up. Chi-square test was performed on each clinical index.The statistically significant indexes were then analyzed by multivariate logistic regression analysis to find out therisk factors for the recurrence of HSP. Results During the follow-up period of 1 year, there were HSP recurrence in27 cases (34.6%) and no recurrence in 51 cases (65.4%). There were significant difference in the allergen test results,family history, eosinophil number, respiratory tract infection, prevention medication, diet control, and strenuous exercisebetween the two groups (P<0.05); but there was no significant difference in white blood cell count, platelet count,and hormone use (P>0.05). Multivariate logistic regression analysis showed that respiratory tract infection after treatment,no prevention medication, no diet control, increased eosinophils were the risk factors of HSP recurrence (P<0.05). Conclusion Avoiding infection, drug prevention, diet control, and limiting strenuous exercise can reduce the recurrencerate of HSP.%目的 观察小儿过敏性紫癜(HSP)预后情况,分析其引起复发的危险因素,为临床干预及预防提供依据.方法 收集阳江市人民医院2014年5月至2016年5月收治的78例过敏性紫癜患儿的临床资料(包括门诊随访及住院情况),随访1年后将其分为复发组和无复发组,将各临床指标行χ2检验,结果具有统计学意义的指标再行多因素Logistic回归分析,找出HSP复发的相关危险因素.结果 门诊随访1年期间,HSP复发27例(34.6%),无复发51例(65.4%).复发组患儿的过敏源检查结果、家族史、嗜酸性粒细胞数目、呼吸道感染、预防用药、控制饮食、限制运动与无复发组比较差异均有统计学意义(P<0.05);两组患儿的性别、白细胞计数、血小板计数、激素使用与否比较差异均无统计学意义(P>0.05);多因素Logistic回归分析结果显示,治愈后有呼吸道感染、未预防用药、未限制饮食、嗜酸性粒细胞持续升高是HSP复发的危险因素(P<0.05).结论 HSP容易复发,HSP治愈后避免感染、行药物预防、限制饮食及避免剧烈运动可降低复发率.