影响儿童过敏性紫癜复发的临床相关危险因素及预防措施

摘要

目的 分析影响儿童过敏性紫癜复发的危险因素并据此探讨预防措施.方法 选取2015年5月至2016年5月湖南省儿童医院儿科就诊的20例复发过敏性紫癜患儿作为研究对象并设为观察组,另选同期健康体检的50例儿童作为对照组,采用Logistic回归分析模型对儿童过敏性紫癜复发危险因素进行分析,探讨相应的预防措施.结果 两组受试者性别、年龄相比较,差异无统计学意义(P>0.05),免疫学指标、血常规、尿蛋白、血脂、食物不耐受相比较,差异有统计学意义(P<0.05);Logistic回归分析结果提示,食物不耐受、病理性蛋白尿为儿童过敏性紫癜复发的独立风险因素(P<0.05).结论 特异性IgG抗体检测、消除机体炎症反应将有助于降低儿童过敏性紫癜复发率.%Objective To analyze the risk factors affecting the recurrence of Henoch-Schonlein purpura(HSP) in children and to explore the preventive measures.Methods Twenty patients with recurrent allergic purpura who were treated from May 2015 to May 2016 in Hunan Children's Hospital were enrolled in this study as the observation group.Fifty healthy children from Hunan Children's Hospital were selected as the control group.Logistic regression analysis was used to analyze the recurrence risk factors of allergic purpura in children, and the corresponding preventive measures were discussed.Results There was no significant difference in sex and age between the two groups(P>0.05).There were significant differences in immunological parameters, routine blood test, urinary protein, blood lipid and food intolerance(P<0.05).Logistic regression analysis showed that food intolerance and pathological proteinuria were independent risk factors for recurrence of allergic purpura in children(P<0.05).Conclusion Specific IgG antibody detection and elimination of inflammation of the body will help reduce the recurrence rate of allergic purpura in children.