西吡氯铵含漱液对常见肠道细菌及部分ESBL+株的抗菌活性研究

摘要

Objective The in vitro antimicrobial activity of 0.1% cetylpyridinium chloride was determined against Escherichia coli, Klebsiellar pneumonia, Proteus vulgaris, Enterococcus faecalis and some clinical isolates.Methods Micro both dilution method.Results For most strains, The MICs of cetylpridinium chloride reach 15.63 μg/mL.Conclusion 0.1% of cetylpyridinium chloride has significant antibacterial effect on common Enteric bacillis, and this is helpful to expand its clinical application.%目的：检测0.1%西吡氯铵洗漱液对大肠埃希菌、肺炎克雷伯菌、变形杆菌、粪肠球菌标准株及部分临床分离ESBL+株（超广谱β-内酰胺酶）的抗菌活性。方法参考NCCLS标准，以微量肉汤稀释法进行检测。结果西吡氯铵对上述各种细菌有较好抑制效果，绝大多数菌株为15.63μg/mL。结论0.1%西吡氯铵洗漱液能有效抑制常见肠道细菌及其耐药株的生长，具有较好的抗菌活性，可进一步拓宽其在临床消毒中的应用。