12例原发性肺淋巴上皮瘤样癌的临床病理分析

摘要

目的：分析总结12例原发性肺淋巴上皮瘤样癌（LELC）的临床病理特点。方法回顾性分析12例肺 LELC 患者的临床病理资料。结果12例肺 LELC 患者的组织学标本中，肿瘤细胞均明显表达 HCK，原位杂交EBER 阳性率为91.7％。全组中位生存期61.3个月，2年和5年生存率分别为84.6％和57.7％。结论原发性肺LELC 临床罕见，发病可能与 EB 病毒感染有关，经及时治疗有较好的预后。%Objective To investigate the pathological and clinical significance of 12 cases with primary Lymphoepithe-lioma-like carcinoma of the lung (LELC). Methods Retrospectively detectded and analyzed the clincalpathological feature of 12 cases of LELC of the lung. Results Histological study showed that tumor cells were significantly expressed HCK by im-munohistochemistry staining and showed out 91.7% positive rate of EBER by situ hybridization.In this series,the median sur-vival time was 61.3 months.The overall 2 and 5 year survival rates of the 12 cases were 84.6% and 57.7%. Conclusion Pulmonary LELC is very rare.It may be associated with Epstein-Barr virus infection,and has a batter prognosis after therapy.