2-氨基-4-异丙基-5-溴苯甲酸的合成

摘要

The target compound of 2 -amino -4 -isopropyl -5 -bromobenzoic acid was synthesized from misoprop- ylaniline by reaction with chlora hydrate/hydroxylamine hydrochloride and then by cyclization of Sandmeyer method, bromination and oxidation, the structure of the target compound was confirmed by IR, 1H - NMR and MS. The synthetic procedure was suitable for industrial production for the advantage of avaible materials, shorter routes, convenient operation and lower cost, the overall yield was improved from the reported 28% to 39%.%以间异丙基苯胺为起始原料，与水合氯醛、盐酸羟胺反应后，经Sandmeyer法环合、溴化、氧化得到目标化合物2-氨基-5-溴-4-异丙基苯甲酸。目标化合物的结构经红外光谱、^1HNMR和Ms确证。该合成方法具有原料易得，合成路线短，操作简单，生产成本低廉的优点，总收率由文献报道的28％提高到39％，更适合工业化生产。