树状结构金鸡纳碱催化剂的合成

摘要

手性催化剂负载和回收一直是非常活跃的研究课题.纳米尺寸的树状分子是重要的催化剂载体,具精确、可控的三维结构及特殊的物化性能等特点.金鸡纳碱催化剂在不对称双羟基化、Mannich反应、Diels-Alder等不对称催化反应中有广泛的应用.以不同代数的树状结构的苄醇、1,4-二氯-2,3-二氮杂萘、二氢奎尼丁为原料经烷基化以较高收率制得树状结构金鸡纳碱催化剂,为探讨该类催化剂在不对称催化反应中的催化性能及分离回收奠定了基础.%Supporting and recycling of chiral catalysts are still the most important scientific issues.Nano-size dendrimers serve as a promising type of catalyst support due to their well-defined and tunable three-dimension molecular architectures as well as their unique physical and chemical properties.Cinchona alkaloid catalysts are widely used in asymmetric catalytic reactions such as asymmetric dihydroxylation reaction, Mannich reaction, Diels-Alder reaction. Dendritic cinchona alkaloid catalysts were obtained from different generations of dendritic benzyl alcohols, 1,4-dichlorophthalazine and dihydroquinidine via alkylation reactions with high yields.This work laid the foundation for the application and recycling of the supported chiral catalysts.