C反应蛋白水平与小细胞肺癌患者预后的关系研究

摘要

目的：探讨小细胞肺癌患者血清C反应蛋白（ CRP）水平对预后的影响。方法86例小细胞肺癌患者，于治疗前采用免疫速率比浊法检测患者血清CRP水平，根据CRP水平将患者分为正常组（CRP＜10 mg／L）57例与异常组（CRP≥10 mg／L）29例，分析血清CRP水平与美国东部肿瘤协作组体能状态（ ECOG-PS）评分、肿瘤直径、疾病分期等临床特征的关系，比较正常组与异常组的生存率。结果小细胞肺癌患者血清CRP水平与肿瘤最大径、肺癌分期、血清白蛋白水平及ECOG-PS评分有关（P＜0．05），而与患者年龄、性别及放疗史无关（P＞0．05）。正常组患者的中位生存期为15．43个月，异常组患者中位生存期为9．20个月，两组生存期比较，差异有统计学意义（P＜0．05）。结论 CRP升高可能是影响小细胞肺癌患者预后的危险因素。%Objective To explore the effect of the serum level of C reactive protein( CRP) on the prognosis of patients with small cell lung cancer.Methods Immunoturbidimetry was adopted to detect the serum CRP level among 86 patients with small cell lung cancer before treatment.The patients were divided into normal group(CRP<10 mg/L,n=57) and abnormal group(CRP >or =10 mg/L,n=29) according to their CRP levels.The relationship of serum CRP level with clinical characteristics including ECOG-PS score,tumor diameter and staging of disease was analyzed.The survival rates of normal and abnormal groups were compared.Results The serum CRP level correlated with the maximum diameter of tumor,staging of lung cancer,serum albumin level and ECOG score(P<0.05),but didn′t correlate with patient′s age,gender,or history of radiotherapy in patients with small cell lung cancer(P>0.05).The median survival time was 15.43 months in the normal group,which was 9.20 months in the abnormal group,there was significant difference in the survival time between two groups (P<0.05).Conclusion The increase of CRP might be a risk factor for the prognosis of patients with small cell lung cancer.