目的 探讨子痫前期孕妇的血脂、血糖与维生素A、E的水平及其临床意义.方法 纳入孕产妇5000例,根据子痫前期发病情况分为子痫前期组500例与对照组4500例,比较两组的血清维生素A、E水平和血糖、血脂水平,分析子痫前期孕妇维生素A、E水平与血脂、血糖水平的相关性.结果 子痫前期组的血清维生素A、E及HDL水平均低于对照组,而TC、TG、LDL、FBG水平均高于对照组(均P<0.05).子痫前期孕妇的血清维生素A、E水平与LDL、FBG、TG水平呈负相关(P<0.05),与HDL水平呈正相关(P<0.05).多重线性回归分析显示子痫前期组的维生素A、E水平均与LDL、FBG水平呈负相关(P<0.05).结论 子痫前期孕产妇孕期维生素A、E水平低,且血脂与血糖水平紊乱,两者可能共同参与了子痫前期的发生发展.%Objective To investigate the expression levels and clinical significance of blood lipids ,blood glucose ,vitamin A and E in pregnant women with preeclampsia .Methods A total of 5000 pregnant women were enrolled and were divided into preeclampsia group (n=500) and control group(n=4500) according to the incidence of preeclampsia .The levels of serum vitamin A and E ,blood glucose and blood lipids were compared between the two groups .The correlation of vitamin A and E levels with blood glucose and blood lipids levels was analyzed in the pregnant women with preeclampsia .Results The serum vitamin A and E ,HDL levels were lower while the TC , TG,LDL and FBG levels were higher in the preeclampsia group compared to the control group (all P<0.05).In the pregnant women with preeclampsia,the serum levels of vitamin A and E negatively correlated with the levels of LDL ,FBG and TG(P<0.05),and positively correlated with the levels of HDL (P <0.05).Multiple linear regression analysis showed that the levels of vitamin A and E in the pre-eclampsia group negatively correlated with the levels of LDL and FBG (P<0.05).Conclusion Reduced vitamin A and E levels, dyslipidemia and dysglycemia are observed in the pregnant women with preeclampsia , and are probably involved in the incidence and progression of preeclampsia .
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