难治性胃食管反流病患者常见食管动力障碍调查

摘要

Objective To investigate and study the related factors of the clinical characteristics of esophageal motility disorders in patients with refractory gastroesophageal reflux. Methods 87 cases of patients with refractory gastroesophageal reflux were studied. The incidence of esophageal motility disorders and the types of the disorders were diagnosed and investigated. The number of acid reflux, acid exposure time and the average duration of esophageal acid clearance ( EAC ) were compared between patients with esophageal motility disorders and patients with normal esophageal motility. Results The incidence rate of esophageal motility disorders ( 64. 37%) was higher than that of normal esophageal motility (P<0. 05);In the types of esophageal motility disorders, the rate of inefficient low pressure and weak motility ( 60. 71%) was significantly higher than that of complete loss of motility and fragmental motility (P<0. 05);The times of acid reflux (6. 1 ± 3. 3) times, acid exposure time (36. 4 ± 8. 3) min and EAC (7. 1 ± 2. 4) min/times of the esophageal motility disorders group were significantly higher than those of the normal esophageal motility group ( P <0. 05 ) . Conclusion Lnefficient low pressure and weak motility is common in esophageal motility disorders. The times of acid reflux, exposure time and abnormal EAC or too high are the related risk factors causing esophageal motility disorders.%目的：调查研究难治性胃食管反流病患者常见食管动力障碍的临床特性相关因素。方法选取87例难治性胃食管反流病患者，诊断调查出现食管动力障碍的发病情况和动力障碍类型，并比较食管动力障碍患者和食管动力正常患者的酸反流次数、酸暴露时间以及平均食管酸清除时间(EAC)指标。结果食管动力障碍发病率64．37%，较食管动力正常率高(P<0．05)；食管动力障碍类型中无效低压弱蠕动收缩60．71%，较完全性失蠕动收缩和片段蠕动均高(P<0．05)；食管动力障碍组酸反流次数(6．1±3．3)次、酸暴露时间(36．4±8．3)min、 EAC(7．1±2．4)min/次，较食管动力正常组均高(P<0．05)。结论食管动力障碍类型多以无效低压弱蠕动收缩为主，酸反流次数、暴露时间和EAC异常过高可能是导致食管动力障碍的危险相关因素。