ATP10D基因多态性与广东地区汉族人群冠心病的关联性

摘要

Objective To investigate the association between the single nucleotide polymorphism (SNP) of ATP10D, rs2351791 and coronary heart disease ( CHD ) in Guangdong Han population.Methods A tagSNP (rs2351791) was picked out from ATP10D gene.Using the TaqMan probe genotyping method , this SNP was genotyped in 664 CHD cases and 657 health controls of Han origin , collected in Guangdong province.Chi－square test and logistic re-gression model were employed for statistical analysis.Results The frequencies of CC, CA and AA in CAD group were 50.2%, 41.4%and 8.4%, respectively; and 48.0%, 43.3%, 8.6%, respectively, in control group.No significant difference was observed in frequency of ATP 10D rs2351791 genotypes between cases and controls (P＞0.05).Allele fre-quencies of A and C were not significantly different between the case group and the control group (OR＝1.05, 95%CI＝0.76－1.33).Furthermore, after adjustment of sex, age, smoking, hypertension and diabetes, rs2351791 was not signif-icantly associated with CHD under different genetic models ( additive, dominant and recessive ).Conclusion Genetic polymorphism of ATP10D rs2351791 is not associated with coronary heart disease in the Han ethnical group in Guangdong Province.%目的 探讨广东地区汉族人群 ATP10D基因多态性与冠心病的关联性.方法 采用 TaqMan探针基因分型技术,在664例冠心病患者(观察组)和657例健康对照(对照组)中对筛选的1个ATP10D基因tagSNP(rs2351791)进行基因型分型,应用 x2检验、logistic 回归模型分析 SNP 位点与冠心病的关联性.结果 CC、CA、AA 在观察组分布频率分别是50.2%、41.4%、8.4%,在对照组中分别为 48.0%、43.3%、8.6%,两组间基因型频率分布差异无统计学意义(P＞0.05);等位基因A和C在观察组和对照组中的分布频率差异无明显相关性( OR ＝1.05,95%CI ＝0.76 ～1.33).校正性别、年龄、吸烟史、血压、血糖后,发现rs2351791在不同遗传模型下基因型关联性分析(加性、显性、隐性)中的差异均无统计学意义[ OR(95%CI)分别为 0.94 ( 0.69 ～1.28),0.99 ( 0.66 ～1.47 ),0.77 ( 0.38 ～1.55 )].结论 在广东地区汉族人群中, ATP10D基因的rs2351791位点与冠心病的遗传易感性无显著性关联.