抗生素的抗菌作用显著，但其毒副作用、所引起的二重感染及细菌的耐药等问题，使其应用受到一定限制。从单味中药及单体化合物、中药复方制剂的抑菌实验3方面的研究已证实多种中药均具有抗菌作用，且具有不易产生耐药的特点与优势。研究还发现，中药的抗细菌作用机制不同于抗生素，其作用机理较为复杂，表现为对细菌的直接抑杀、抑制酶的活性、逆转耐药机制和调节机体免疫功能等多种作用综合的结果。本文就近年来中药制剂的抗菌作用、抗菌活性成分及其抗菌机制进行综述。%Although the antibacterial effect of antibiotics is remarkable, its application is restricted the due to the obvious side effects such as superinfection and the drug resistance of bacteria, etc. . A variety of traditional Chinese medicine have the antibacterial effect less drug resistance from single herb, monomer compounds to compound preparation, which have been confirmed by Bacteriostatic experiment. The studies also found that the mechanism of anti-bacteria effect of traditional Chinese medicine( TCM) is different from antibiotics, which are more complex, like direct killing bacteria, suppressing enzyme activity, reversing drug resistance and regulating immune function. The antibacterial components and anti-bacterial mechanism of Chinese medicine were reviewed in this paper.
展开▼
