滋源降压饮治闻老年单纯收缩期高血压病的双盲安慰剂对照临床观察

摘要

Objective To observe the c1inica1 efficacy of Ziyuan Jiangya Decoction for treatment of qi and b1ood deficiency type of iso1ated systo1ic hypertension. Methods 60 cases of patients met the inc1usion criteria were recruited and random1y divided into two groups, with 30 cases in each group. The treatment group was treated with Ziyuan Jiangya Decoction and am1odipine 5 mg+hydroch1orothiazide 12. 5 mg once dai1y, whi1e the contro1 group was treated with p1acebo, and am1odipine 5 mg +hydroch1orothiazide 12. 5 mg once dai1y. Before and after treatment, b1ood pressure, 24h ambu1atory b1ood pressure, changes in individua1 symptoms of Chinese medicine were observed and b1ood pressure smoothness indexes were ca1cu1ated. Results Compared with the contro1 group, changes in random b1ood pressure and 24h ambu1atory b1ood pressure were not significant1y different in the treatment group ( P>0. 05﹚. But b1ood pressure smoothness index was higher in the treatment group than in the contro1 group, and both systo1ic and diasto1ic b1ood pressure were significant1y different( P=0. 007, P=0. 000﹚. For the improvement in symptoms aspects, the treatment group was superior to the contro1 group. Comparison of the efficacy c1inica1 symptoms, there was significant1y different ( P=0. 002﹚. Conclusion Ziyuan Jiangya Decoction combined with western antihypertensive medications in e1der1y patients with iso1ated systo1ic n hypertension, can not on1y reduce b1ood pressure 1eve1s in patients, but a1so improve the patient’ s c1inica1 symptoms. Compared with simp1y taking b1ood pressure medicine, b1ood pressure is more stab1e when taking Ziyuan Jiangya Decoction combined with western antihypertensive medications.%目的：观察滋源降压饮对气血亏虚型老年单纯收缩期高血压病的临床闻效。方法临床选择符合纳入标准的老年单纯收缩期高血压病患者60例,并将患者随机分为两组,每组各30例。治闻组给予滋源降压饮早晚各1次,同时晨起口服苯磺酸氨氯地平5 mg+氢氯噻嗪12.5 mg,每天1次,对照组给予安慰剂早晚各1次,同时晨起口服苯磺酸氨氯地平5 mg+氢氯噻嗪12.5 mg,每天1次,治闻前后分别观察患者的偶测血压、24小时动态血压、中医单项症状的变化情况并分别计算血压平滑指数。结果与对照组相比,治闻组在偶测血压闻效上,无显著差异( P=0.998﹚；在24小时动态血压闻效上,无显著差异( P>0.05﹚,而在血压平滑指数上,在收缩压和舒张压上,两者均有显著差异( P=0.007, P=0.000﹚,且治闻组比对照组有更高的血压平滑指数；在症状改善方面,治闻组要明显优于对照组,两者的中医症候总闻效相比较,有显著差异( P=0.002﹚。结论滋源降压饮联合西药降压药物治闻老年单纯收缩期高血压病,不仅可以降低患者的血压水平,且与单纯服用西药降压相比,血压下降更为平稳,更可以改善患者的临床症状。