EFFECT OF TARGETED PULSED ELECTROMAGNETIC FIELD THERAPY ON CANINE POST-OPERATIVE HEMILAMINECTOMY: A DOUBLE-BLIND, RANDOMIZED, PLACEBO-CONTROLLED CLINICAL TRIAL

摘要

Intervertebral disk disease (IVDD) is the most common spinal cord injury of dogs and leads to pain, paralysis and morbidity. The severity of spinal cord dysfunction following disc extrusion has been attributed primarily to spinal cord compression andsubsequent swelling and inflammation of the cord. Multiple human clinical trials have demonstrated the potential for PEMF therapy to promote wound healing and reduce pain and inflammation. One possible mechanism of action for PEMF is via upregulation ofthe voltage dependent binding of calcium to calmodulin, which downregulates inducible nitric oxide (iNOS) synthase and reduces IL-ip and other inflammatory cytokines. PEMF has also been shown to stimulate regeneration of peripheral nerves and improve function in animals following spinal cord injury.