模拟移动床色谱及其在茶叶功能成分分离中的应用前景

摘要

Simulated moving bed chromatography,developed in the 1960s,is a kind of continuous preparative chromatography with multiple advantages,such as improving product purity and recovery rate,increasing separation efficiency and reducing costs.This technology has been extensively used in the petrochemical,food and pharmaceutical industries,but has not yet been applied to separate functional components of tea.Current studies have demonstrated the successful separation of catechin by using simulated moving bed chromatography.In this paper,separation principles and application progress at home and abroad of simulated moving bed chromatography are summarized.Meanwhile,its application prospects in the separation of functional components from tea are also discussed.Therefore,simulated moving bed chromatography will become a major research direction for the preparation of catechin and theaflavin.%模拟移动床色谱是20世纪60年代发展起来的能实现连续分离的一种制备色谱,具有提高产品纯度和回收率,提高分离效率和降低成本等优点。该技术已经在石油化工和食品医药等领域有重要应用,但是尚未被应用到茶叶功能成分的分离。目前,有研究表明模拟移动床色谱能用于分离儿茶素。本文综述模拟移动床色谱的分离原理和国内外的应用进展,并分析该方法在茶叶功能成分分离中的应用前景。模拟移动床色谱将成为儿茶素单体和茶黄素单体制备研究的主要方向。