A sensitive and rapid method for the simultaneous determination of 8 biogenic amine residues in aquatic products was established using an ultra-high performance liquid chromatography (UPLC) system. Aquatic product samples were ex- tracted with perchloric acid solution, centrifugated, defatted with n-hexane and derivatized with dansyl chloride. The derivative was allowed to react with ammonia water and made up to the desired volume with acetonitrile. A 5 /a L sample was injected and separated in a gradient elution mode. The detection wavelength was set as 245 nm. The results showed that 8 biogenic amines displayed a linear relationship in the range of 0.5- 20 μtg/mL with correlation coefficients not lower than 0.999. The spike recovery rates of 8 biogenic amines were in the range of 71.99% - 97.65% with intra-batch precision RSD of 0.15% - 8.89% and inter- batch precision RSD of 1.55% - 10.7% (n = 6). The limit of detection was 15.0 μtg/kg for Try and Phe, 6.0/μg/kg for Put, Cad and His, and 20.0 μg/kg for Try, Spd and Spm. This method was rapid, simple, sensitive, repeatable and accurate and the analysis process could be completed in 13 min. Thus, it is suitable for the rapid and large-scale determination of biogenic amine residues in aquatic products.%应用超高效液相色谱检测平台，建立同时测定水产品中8种生物胺的高灵敏度快速检测。水产品肉组织经高氯酸溶液冰冻离心提取后，正己烷除脂，丹磺酰氯溶液衍生。氨水结束反应，乙腈定容，进样量5μL，梯度洗脱，紫外检测波长245nm。结果显示：8种生物胺分别在0．5～20μg，mL范围内线性良好，相关系数r≥O．999；8种生物胺加标回收率为71．99％～97．65％，批内精密度为O．15％～9．89％，批间精密度为1．55％～10．7％m=6）；8种生物胺的检出限（RsN=3）：色胺、苯乙胺15．0μg／kg，尸胺、腐胺、组胺6．0μg／kg，酪胺、精胺、亚精胺20．0μg／kg。该方法快速简便，灵敏度高、重复性和准确性好，13min完成分析，适合水产品中生物胺含量的大批量快速的检测分析，检测效率成倍提高。
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