天然产物与microRNA调控代谢综合征的研究进展

摘要

代谢综合征已成为全球性的健康问题.microRNA (miRNA)是一类能够调节基因表达的短单链内源非编码RNA(约22 nt),在转录后水平调节基因表达.miRNA在代谢综合征中发挥重要作用,药食同源的天然产物可以通过调控miRNA的活性和功能,改善糖脂代谢紊乱.本文主要综述miRNA在糖尿病、肥胖等代谢综合征的致病机制中的研究进展,深入分析了药食同源的天然产物对miRNA的调控机制,可为发掘miRNA在代谢综合征预防、诊断、治疗中的潜在价值提供理论依据.%The metabolic syndrome has become a global health problem.microRNA (miRNA),a short single-stranded endogenously expressed RNA (approximately 22 nt),regulates gene expression at the post-transcriptional level.A lot of researches have shown that miRNA plays an important role in metabolic syndromes.Additionally,natural products which can be used as both food and medicine can modulate the activities and functions of miRNA to improve glucose and lipid metabolism disorders.Recent evidence described in this review highlights the significant role of miRNA in metabolic syndromes and how dietary factors may influence metabolic syndromes by modulating the activities and functions of miRNA.