Objective To prepare mesoporous titanium dioxide (TiO2) and modify the surface with polyethylene glycol (PEG), and use it to load hydrophobic photosensitizer. Methods Mesoporous TiO2 was prepared by hydrolysis at room temperature, using tetra-n-butyl titanate as raw material and cetylpyridinium chloride as template. The surface of TiO2 was modified with PEG. The drug loading conditions were optimized by changing the ratio of solvents and the concentration of the photosensitizer PPa. The efficiency of singlet oxygen production was measured. Results The sedimentation rate of TiO2 significantly decreased after PEG modification and the dispersion stability increased. The optimized encapsulation efficiency was 80.01 ％. After 660 nm laser irradiation, PEG-TiO2/PPa produced a large amount of singlet oxygen. Conclusion The drug delivery system after PEG modification has higher yield of singlet oxygen.%目的 制备介孔二氧化钛(TiO2),对其表面进行聚乙二醇(PEG)修饰,并利用其包载疏水光敏剂.方法 以钛酸丁酯为原料,十六烷基氯化吡啶为模板剂,采用室温水解法制备介孔TiO2;用PEG对TiO2表面进行亲水性修饰;改变溶剂的比例和光敏剂的浓度以优化载药工艺,测定载药后产生单线态氧的效率.结果 PEG修饰后TiO2的沉降速度显著降低,分散稳定性提高;优化后包封率达80.01％;660 nm激光照射后载药TiO2产生大量单线态氧.结论 经PEG修饰后载药系统具有较高的单线态氧产率.
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