PHOTOSENSITIZER-LOADED DENDRIMER-MODIFIED MULTI-WALLED CARBON NANOTUBES FOR PHOTODYNAMIC THERAPY

摘要

Polyamidoamine dendrimer modified multi-walled carbon nanotubes (dMNTs) have been explored as new vehicles to deliver the photosensitizer 5-aminolevulinic acid (5-ALA) to tumor MGC-803 cells. Intense fluorescence of protoporphyrin IX (PpIX) was monitored in the cytoplasm of MGC-803 cells. The nanocarriers possessed good biocompatibility and can significantly increase the accumulation of photosensitizer in tumor cells, leading to remarkable photodynamic anti-tumor effects.