口服药用聚酯瓶标准中乙醛测定方法的改进

摘要

Objective:To improve the determination method of Acetaldehyde in PET bottles for oral preparations.Method:The head-space gas chromatography was adopted.Result:The curve of Acetaldehyde was linear in the range of 0.2-3.0μg (r=0.995 4), the average recovery was 103.2%with RSD of 3.5%(n=9).Conclusion:The improved method is simple, accurate which can be used to control the quality of PET bottles for oral preparations efficiently.%目的：改进现行口服药用聚酯瓶质量标准中乙醛测定方法。方法：采用顶空气相色谱法对乙醛进行含量测定。结果：乙醛进样量在0.2～3.0μg范围内线性良好，r＝0.9954，平均回收率为103.2％，RSD＝3.5％（n＝9）。结论：修订后的方法简便、准确，能够更有效地控制口服药用聚酯瓶的质量。