Objective To probe into the clinical application of B ultrasound guided core needle biopsy in breast masses can be touched. Methods 104 cases with breast mass (mass>5cm) was selected in our hospital both in the ultrasound guided air core biopsy and pathological examination. All the mass in the puncture showed were treated with surgical operation excision. Short term and long-term complications of puncture were observed after operation.Results 107 of breast lesions, biopsy pathology report showed invasive breast cancer tumors 87 (81.3%), the remaining 20 cases showed benign lesions: three inlfammatory lesions, fourteen ifbroadenoma breast hyperplasia, two atypical hyperplasia, three cases of bilateral breast tumor patients, bilateral invasive breast cancer one case, one side of invasive cancer, contralateral ifbroadenomas in two patients, the sensitivity was 99.3%, speciifcity was 100.0%, the negative rate of return of 96.8%, Youden index was 0.97, false negative rate was 0.9%. After puncture site hematoma 2 cases of patients, forty-ifve cases of subcutaneous ecchymosis puncture region appears in the patients, which is no cases of infection.Conclusion In the ultrasound guided core needle biopsy in diagnosis of breast lumps and breast cancer is safe and which is effective clinical method.%目的：探析B超引导空芯针穿刺活检在可触及的乳腺肿块的临床应用价值。方法选取收治的乳腺肿块（肿块>5cm）患者104例，均在超声的引导下行空芯穿刺活检及病理学的检查。肿块在穿刺结果显示后均给予外科手术切除。观察穿刺术后近远期的并发症情况。结果107个乳腺肿块中，穿刺活检病理报告显示浸润性乳腺癌的肿物87个（81.3%），剩余20例为良性病变，14例纤维肿瘤、3例炎性病变、2例乳腺增生、1例不典型增生；双侧乳腺肿物患者中，1例为双侧均为浸润性乳腺癌，2例为一侧浸润性乳腺癌，对侧为纤维乳腺瘤，敏感度与特异性分别为99.3%与100.0%，阴性回报率较高为96.8%，Youden指数为0.97，假阴率为0.9%。穿刺术后出现部位血肿的患者2例，穿刺区出现皮下瘀斑的患者45例，无感染病例。结论在超声引导下行空芯针穿刺活检是诊断乳腺肿块和乳腺癌有效、安全的临床方法。
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