探讨17β-羟类固醇脱氢酶2在子宫内膜息肉中的表达及意义

摘要

ObjectiveTo observe and analyze the 17 beta hydroxy steroid dehydrogenase 2 in the expression and signiifcance of endometrial polyps.MethodsTo select childbearing age women 30 patients with polyps group as research object, and identiifed as the experimental group;Then select 30 cases of normal endometrium tissues as control group. It was evaluated by immunohistochemical method the expression of 17 beta hydroxy steroid dehydrogenase, 2 analysis the research object serum menstruation 2-5 days, electrochemical luminescence immunity analysis method to determine the five sex hormone levels, with Biosens Digital Imaging Systems by the integral optical density of positive values are measured and analyzed.ResultsThe experimental group stage proliferation and secretion of integral optical density value respectively (43.65 ± 4.56) and (102.45 ± 13.50) signiifcantly lower than control group in the same value (113.80 ± 14.54) and (151.23 ± 15.23), and statistically signiifcant difference (P<0.05).ConclusionIntrauterine membrane polyp group was signiifcantly associated with partial abnormal metabolism of estrogen is directly related to organization, 17 beta hydroxy steroid dehydrogenase 2 in integral optical density value decreased obviously in endometrial polyps may be an important factor to affect the occurrence of endometrial polyps, radically reduce intrauterine membrane polyp occurrence or recurrence.%目的：观察和分析17β-羟类固醇脱氢酶2在子宫内膜息肉中的表达及意义。方法选取育龄期妇女息肉组织患者30例作为观察对象，并确定为实验组；再选取正常内膜组织30例，作为对照组。采用免疫组化法测定17β-羟类固醇脱氢酶2的表达，分析研究对象月经第2～5天血清，采用电化学发光免疫分析法测定5项性激素水平，用Biosens Digital Imaging Systems图文对阳性区的积分光密度值进行测定和分析。结果实验组增殖期和分泌期的积分光密度值分别为（43.65±4.56）和（102.45±13.5）明显低于对照组同期值（113.8±14.54）和（151.23±15.23），差异具有统计学意义（P<0.05)。结论宫内膜息肉组织的发生与组织局部雌性激素代谢异常有直接关系，17β-羟类固醇脱氢酶2在子宫内膜息肉中的积分光密度值下降明显可能是导致子宫内膜息肉发生的重要因素，从根本上减少宫内膜息肉的发生或再发。