17.Beta .- 3-propaneamido -substituted estra-1,3,5 (10) -trien-17-one compounds for use as inhibitors of beta.-hydroxysteroid dehydrogenases and 17-oxime

摘要

The present invention relates to compounds of formula (I) and pharmaceutically acceptable salts thereof: Wherein R 1 to R 4 are as defined in the claims. The invention further relates to inhibitors of 17β-HSD1 and of steroid hormone dependent diseases or disorders such as steroid hormone dependent diseases or disorders that require inhibition of 17β-HSD1 enzymes and / or require reduction of endogenous estradiol concentrations. To the use thereof in the treatment or prophylaxis. The invention also relates to the preparation of the abovementioned compounds and to pharmaceutical compositions comprising as active ingredient (s) one or more of the abovementioned compounds or pharmaceutically acceptable salts thereof.