Synthesis and molecular structure study of 3-methoxy-7α-methyl-6-oxa- 9β,14β-estra-1,3,5(10)-trien-17-one in solution

Selivanov S.I.; Morozkina S.N.; Shavva A.G.

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Synthesis and molecular structure study of 3-methoxy-7α-methyl-6-oxa- 9β,14β-estra-1,3,5(10)-trien-17-one in solution

机译：溶液中3-甲氧基-7α-甲基-6-氧杂-9β，14β-estra-1,3,5（10）-trien-17-one的合成及分子结构研究

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It was established by NMR spectroscopy that the catalytic hydrogenation of 3-methoxy-7α-methyl-6-oxa-14β-estra-1,3,5(10),8-tetraen-17-one leads to the formation of 3-methoxy-7α-methyl-6-oxa-9β,14β-estra-1,3, 5(10)-trien-17-one, the structure of which was investigated in solution. The corresponding analog with a free hydroxyl group at the position 3 possesses an antiradical activity at the absence of uterotropic effect.

机译：通过NMR光谱法确定3-甲氧基-7α-甲基-6-氧杂-14β-estra-1,3,5（10），8-丁烯-17-的催化氢化导致3-的形成甲氧基-7α-甲基-6-氧杂-9β，14β-雌激素-1,3，5（10）-三烯-17-一，在溶液中研究了其结构。相应的在3位具有游离羟基的类似物在不存在促同尿作用的情况下具有抗自由基活性。

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《Chemistry of heterocyclic compounds 》 |2012年第5期| 共11页
作者
Selivanov S.I.; Morozkina S.N.; Shavva A.G.;
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正文语种 eng
中图分类杂环化合物 ;
关键词
9β; 14β-analogs of steroidal estrogens; and NOESY methods of NMR spectroscopy; Antiradical activity; DFQ-COSY; HSQCnd; J-COSY; Steroidal estrogen structure determination; Uterotropic activity;

机译：9β;类固醇雌激素的14β类似物;NMR谱的NOESY方法;抗自由基活性;DFQ-COSY;HSQCnd;J-COSY;甾体雌激素结构测定;促尿液活性;

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1. Synthesis and molecular structure study of 3-methoxy-7α-methyl-6-oxa- 9β,14β-estra-1,3,5(10)-trien-17-one in solution [J] . Selivanov S.I., Morozkina S.N., Shavva A.G. Chemistry of heterocyclic compounds . 2012 ,第5期

机译：溶液中3-甲氧基-7α-甲基-6-氧杂-9β，14β-estra-1,3,5（10）-trien-17-one的合成及分子结构研究
2. TOTAL SYNTHESIS AND REACTIVITY OF C(8)-C(14) METHYLENE-BRIDGED DERIVATIVES IN THE 8-ALPHA-ESTRA-1,3,5(10)-TRIENE SERIES [J] . Ruhland T., Kunzer H., Thiel M. Tetrahedron letters: The International Journal for the Rapid Publication of Preliminary Communications in Organic Chemistry . 1995 ,第42期

机译：8-Alpha-Estra-1,3,5（10）-三烯系列中C（8）-C（14）亚甲基桥接的衍生物的总合成与反应性
3. The crystal and molecular structure of 17-thia-3-methoxy-estra-1,3,5(10) triebe-17 dioxide [J] . Padmanabhan V. M., Sinha Surendra Current science . 1983 ,第01期

机译：17-thia-3-methoxymethoxy-estra-1,3,5（10）triebe-17oxide的晶体和分子结构
4. IN VITRO AND IN VIVO ANTI-CANCER EFFECTS OF 2-ETHYL-3-O-SULPHAMOYL-ESTRA-1,3,5(10)15- TETRAENE-3-OL-17-ONE AND 2-ETHYL-3-O-SULPHAMOYL-ESTRA-1,3,5(10)16-TETRAENE [C] . A. E. Theron, L. Lafanechere, R. Prudent, Annual Conference of the Microscopy Society of Southern Africa . 2012

机译：体外和体内抗癌作用为2-乙基-3-O-硫氰酸酯-1,3,5（10）15-四烯-3-醇-17-一和2-乙基-3-O- Sulphamoyl-Estra-1,3,5（10）16-四烯
5. OXIDATION-REDUCTION REACTIONS AND EQUILIBRIUM PHASE RELATIONS AT 1300 DEGREES C AT OXYGEN PRESSURES FROM 0.21 TO 10 EXP(-14) ATMOSPHERES FOR THE SPINEL SOLID SOLUTION SERIES M CHROMIUM(2)OXIDE(4), M = IRON AND MAGNESIUM; AND M ALUMINUM(2) OXIDE(4), M = IRON AND MAGNESIUM. [D] . ULMER, GENE CARLTON. 1964

机译：M氧化铬（2）（4），M =铁和镁的尖晶石型固溶体，在1300摄氏度，氧气压力从0.21到10 EXP（-14）大气压力下的氧化还原反应和平衡相关系;和M铝（2）氧化物（4），M =铁和镁。
6. 3-Iodo-8β9α14α-estra-135(10)-trien-17-one [O] . Kamal Aziz Ketuly, A. Hamid A. Hadi, Seik Weng Ng 2009

机译：3-碘8β9α14α-额外的135（10）-trien-17-one
7. 3-Iodo-8β,9α,14α-estra-1,3,5(10)-trien-17-one [O] . Kamal Aziz Ketuly, A. Hamid A. Hadi, Seik Weng Ng 2009

机译：3-碘8＆＃946，9安培;＃945，14安培;＃945;雌-1,3,5（10） - 三烯-17-酮
8. Synthesis of nido- and closo-diplatinacarborane Complexes by Direct Insertion; Crystal and Molecular Structures of closo-2-3-((Et3P)2)2-1-2-3-6-CPt2CB5H7-nido-4-8-((Me3P)2Pt)-8- 8((Me3P)2)-7-8-10-CPtCB8H10 and nido-8-8-((Me3P)2)-7-8-10-CPtCB8H10. [R] . Barker, G. K., Green, M., Spencer, J. L., 1975

机译：直接插入法合成nido-和closo-diplatinacarborane配合物; closo-2-3 - （（Et3p）2）2-1-2-3-6-Cpt2CB5H7-nido-4-8 - （（me3p）2pt）-8-8（（me3p）2的晶体和分子结构）-7-8-10-CptCB8H10和nido-8-8 - （（me3p）2）-7-8-10-CptCB8H10。

Synthesis and molecular structure study of 3-methoxy-7α-methyl-6-oxa- 9β,14β-estra-1,3,5(10)-trien-17-one in solution

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