纤维蛋白原基因FGG 10034 C>T基因多态性与缺血性脑卒中的关系的研究

摘要

Objective To explore the relationship between the polymorphism offibrinogen gene FGG10034C > T and ischemic stroke, looking for genetic susceptibility factors of ischemic stroke, in order to elucidate the pathogenesis of ischemic stroke based on molecular level.Methods Fibrinogen gene FGG10034C > T polymorphism was determined by PCR-RFLP in 100 cases of ischemic stroke and 100 controls selected form Binzhou medical school affiliated hospital.Results The frequencies of FGG10034 T/T genotype and T allele in the groups of ischemic stroke group were 14.0%and 33.5%, which were significantly higher than control group (P< 0.05).Conclusion There is correlation between thefibrinogen FGG10034 C>T polymorphism and ISFGG10034 C>T may be a gnetic risk factors of stroke.%目的：探讨纤维蛋白原基因FGG10034C>T基因多态性与缺血性脑卒中的关联性，寻找缺血性脑卒中的遗传易感性因素，以期从分子水平阐明缺血性脑卒中的发病机制。方法回顾性收集100例临床诊断为缺血性脑卒中(IS)的患者资料作为病例组及101例健康查体者的临床资料作为对照组，应用聚合链反应-限制性片段长度多态性（PCR-RFLP）进行基因多态性分析。结果 FGG10034C>T位点T/T基因型及T等位基因在缺血性脑卒中组出现的频率(分别为14%、33.5%)明显高于对照组，差异有统计学意义（P<0.05）。结论纤维蛋白原基因FGG10034C>T位点与缺血性脑卒中有关联，可能是一个遗传学的危险因素。