临床药师参与1例硝苯地平与氟康唑联用引起低血压的药学实践

摘要

Objective:To investigate the cause and treatment of hypotension induced by combined use of nifedipine and lfuconazole to avoid the recurrence of similar interactions.Methods:Medication analysis was conducted in one case with hypertension and fungal infection who had hypotension after combined nifedipine and lfuconazole therapy.Results: Combined use of triazole antifungal drugs and calcium channel blockers may cause drug interactions and lead to an increase in plasma concentration of calcium channel antagonists which may cause hypotension.Conclusion: The treating team composed of clinical pharmacists and doctors can better protect the safety of patient medication.%目的:探讨硝苯地平与氟康唑联用引起低血压的发生机制及处理方法,避免类似相互作用再次发生.方法:通过分析临床药师参与的1例高血压合并真菌感染患者经硝苯地平和氟康唑联合治疗后出现低血压,进行用药分析排查.结果:三唑类抗真菌药和钙离子通道阻断剂合用存在药物间的相互作用,可使钙通道拮抗剂的血药浓度升高,导致血压下降.结论:临床药师与医生组成治疗团队,能更好地保障患者的用药安全.