The composition of a vaginal gel containing drug combination for the treatment of vaginal candidiasis caused by strains sensitive and resistant to fluconazole

摘要

The composition of a vaginal gel containing drug combination for the treatment of vaginal candidiasis caused by strains sensitive and resistant to fluconazole.The vulvovaginal candidiasis (VVC) is a common diagnosis in gynecology.It is estimated that 75% of women in the adult stage showed at least once in a lifetime, some episodes of infection.The main causative agent of VVC is Candida albicans, however the non albicans species, are getting the emphasis on clinical medicine.Within this framework, was developed a semisolid pharmaceutical form based on fluconazole and amiodarone for vaginal use.The gel developed has a polymer geleificante, preservative system, co solvent, active and the causative agent of synergism.According to the data physical chemical formulation offers the behavior type pseudoplástico, compatible with the vaginal pH,The content of active substance and synergistic agent is between 95 to 105% of the declared value.A speed of in vitro release of 294 and 1147 GG / min 1 / 2 and halos of inhibition in the range of 2299 the 2816 cm.The gel was developed in the present invention.With the combination of active agent and synergistic antifungal activity against presents a strains of Candida spp susceptible and resistant to the active administered alone.