Objective The aim of study was to explore the relationship between the number of megakaryocytes in bone marrow smear and clinical therapeutic effect of adult paients with idiopathic thrombocytopenic purpura(ITP). Methods A series of data of 94 patients with adult ITP including the counts of the megakaryocytes at diagnosis and the counts of peripheral platelets at pretreatment and after treatment were collected and retrospectively analyzed to correlate with the clinical outcome. Results The number of megakaryocytes in bone marrow smear was increased in 74 cases among 94 cases,and the percentage was 78.72％. The effective rate of treatment in 94cases was 80.85％. The number of megakaryocytes in bone marrow smear between the patients of the obvious effect and the patients of no effect was significantly different (P＜0.05). Conclusion The results showed that number of megakaryocyte in bone marrow smear has obvious influence on treatment of adult ITP. It is concluded that the number of megakaryocyte in bone marrow smear can forecast the therapeutic effect of patients with adult ITP.%目的 探讨成人特发性血小板减少性紫癜(ITP)患者的骨髓巨核细胞数量和分布特点及其与临床疗效之间的关系.方法 收集近几年收治的确诊为ITP的94例成年住院患者资料进行回顾性分析总结.结果 94例成人ITP患者中有74例的骨髓巨核细胞增多,占78.72%,且以成熟的产板型巨核细胞减少或缺如,较幼稚的颗粒型巨核细胞显著增多为特点.94例中显效42例(44.68%),良效24例(25.53%),进步10例(10.64%),无效18例(19.15%).总有效率80.85%.显效者骨髓巨核细胞增多者占76.19%,而无效者骨髓巨核细胞增多者比例为55.55%,二者比较差异有统计学意义(P<0.05).结论 ITP患者治疗前骨髓巨核细胞的数量及幼稚和成熟巨核细胞比例与临床疗效密切相关.
展开▼
