男性2型糖尿病代谢综合征组分对骨密度的影响

摘要

目的 观察男性2型糖尿病(T2DM)患者合并不同数目代谢综合征(MS)组分者腰椎骨密度(BMD)的变化及其影响因素.方法 将228例男性T2DM患者根据合并MS组分数目不同,分为不伴有其它MS组分的单纯T2DM组(G0组),合并1个组分的T2DM组(G1组),合并2个组分的T2DM组(G2组),合并3个组分的T2DM组(G3组),分析各组腰椎BMD变化.结果 随着合并MS异常组分的增多,BMD、血钙呈上升趋势,差异有统计学意义(P<0.05);相关分析显示,腰椎BMD与体质量指数(BMI)、体质量、腰臀比(WHR)呈正相关,与血钙、血磷及糖基化血红蛋白(HbAlc)水平呈负相关;多元逐步回归分析显示,体质量、HbAlc、血钙、血磷为影响腰椎BMD的独立相关因素(P<0.05).结论 T2DM合并MS患者BMD增加,肥胖对骨量有一定的保护作用.%Objective To investigate the effects of the different numbers of metabolic syndrome(MS) components-complicating male patients with type 2 diabetes on L2-4 bone mineral density(BMD) and to analyze the relevant influential factors. Methods 228 male patients with type 2 diabetes were grouped according to the metabolic abnormalities. The diabetes patients without any other metabolic abnormalities were in group 0. Those with one to three other metabolic abnormalities were divided to group 1, group 2 and group 3. The changes of L2-4 bone mineral density(BMD) and their risk factors were analyzed. Results Body mass index(BMI), L2-4 bone mineral density(BMD) and blood calcium were increased according to the increasing numbers of MS components(P＜0.05); L2-4 BMD was positively correlated with BMI, weight and WHR. It was negatively correlated with blood calcium, blood phosphorus and HbAlc. The multiple stepwise regression analysis demonstrated that L2-4 BMD was strongly correlated with weight, HbAlc,blood calcium and blood phosphorus. Conclusion The bone mineral density significantly increases in type 2 diabetic patients with metabolic syndrome, and obesity may be an important protective factors.