血栓调节蛋白和纤维蛋白原在原发性肾病综合征中的相关性研究

摘要

Objective To discuss the correlation and the expression of serum soluble thrombomodulin(sTM) and fibrinogen in idiopathic nephrotic syndrome(INS) , and to analyze the realationship between them and renal pathology type in the patients with INS. Methods 60 cases of INS diagnosed by renal biopsy and immunopathology and 30 healthy controls serums were examined sTM by enzyme linked immunosorbent assay(ELISA). Results Serum sTM level in the INS group was significantly higher than that in the healthy control group(P<0. 05). Among them, serumsTM level in the MN group was lower than that in other groups of INS (P<0. 05). The correlation analysis of serum sTM and FG in the MsPGN and Mngroups of INS patients showed that sTM was negatively correlated with fibrinogen(FG) (r= -0.075, r= -0. 190 ,P<0. 05). Conclusion Serum sTM level not only can be used as the sensitive indicators in the damage of glomerular endothelial cells,but also provides some guidance for clinical observation indicators of MsGPN and MN types of INS complicating thrombosis and embolism .%目的 探讨血清可溶性血栓调节蛋白(sTM)及纤维蛋白原(FG)在原发性肾病综合征(INS)中的表达水平及相关性,分析其与INS患者肾组织病理类型之间的关系.方法 60例经肾穿刺活检及免疫病理明确诊断的INS患者与30例健康对照组,采用酶联免疫吸附法(ELISA)检测其sTM水平.结果 INS患者血清sTM水平显著高于健康对照组(P＜0.05),其中MN组患者血清sTM水平低于INS其他各组(P＜0.05);INS患者MsPGN组、MN组患者血清sTM与FG的相关性分析显示,sTM与FG呈负相关(r= -0.075、r= -0.190,P＜0.05).结论 sTM水平不仅可以作为肾小球血管内皮细胞损伤的敏感指标,而且可以为MsGPN、MN类型的INS并发血栓和栓塞的临床观察指标提供一定的指导依据.