Control of Venous Thromboembolism and Metastasis in Breast Cancer by Antifibrinolysis Mechanism.

摘要

Formation of abnormal clots in vessels is a life-threatening situation and the second leading cause of death in cancer patients and is particularly common in breast cancer. Clot formation may also enhance tumor cells spread throughout the body. This study shows a tumor-related cell surface enzyme FAP as a potential contributor to abnormal clot formation and tumor cell survival and growth in blood mimics. Base on its results, new tests can be developed to identify breast cancer patients at high risk of developing abnormal clots. These patients can benefit most from preventive treatments. Also, agents specifically inhibiting the above enzyme have been investigated in this project to evaluate their use in preventing abnormal clot formation.