目的 观察在并发有新生儿呼吸窘迫综合征(NRDS)的早产儿中,不同首次剂量固尔苏的临床效果.方法 将胎龄小于36周,生后3 d内诊断为早产儿呼吸窘迫综合征的40例患儿随机分为治疗组和对照组,前者在确诊NRDS后即给予固尔苏200 mg/kg治疗,后者给予固尔苏100 mg/kg治疗,若病情无明显改善可在每12小时后再次给予固尔苏100 mg/kg,但总量不得超过400 mg/kg.具有机械通气指征时均予行机械通气.结果 治疗组患儿需要接受第2、3剂固尔苏治疗的比例以及平均机械通气时间.平均吸氧时间均低于对照组(P<0.05);治疗组血气分析结果较对照组明显改善(P<0.05);胸片结果也明显优于对照组;两组患儿严重并发症的累积发生率比较差异无统计学意义(P>0.05).结论 对于确诊为NRDS的早产儿,首次给予固尔苏治疗剂量(200 mg/kg)可减少再次用药比例,改善患儿血气分析及胸片结果,缩短早产儿机械通气时间及氧疗时间,值得临床广泛推广.%Objective To observe the clinical effects of different first doses of curosurf in treating premature neonatal respiratory distress syndrome(NRDS). Methods 40 newborns with gestational age less than 36 weeks were diagnosed as NRDS within 3 d after born and divided into the therapy group and the control group. The therapy group was given curosurf 200mg/kg, while the control group was given curosurf 100 mg/kg, but the total dose did not exceed 400mg/kg. Results The ratio needing the second and third doses of curosurf, the average time of mechanical ventilation and oxygen inhalation in the therapy group were lower than those in the control group, showing statistical difference (P<0. 05). The results of chest X-ray in the therapy group also was obviously superior to the control group. The difference in cumulative incidence rate of complications had no statistical significance between two groups (P>0. 05). Conclusion Premature neonates diagnosed as NRDS receiving curosurf of 200 mg/kg as the first dose can decrease the ratio of receiving curosurf again, decrease the time of mechanical ventilation and oxygen inhalation, which is worth spreading in clinic.
展开▼
