血清hs-CRP、GSP、Apo A、HDL-C与2型糖尿病合并急性心肌梗死治疗转归的相关性研究

摘要

Objective To explore the correlation between hs-CRP, GSP, Apo A, HDL-C and treatment outcome of AMI with T2DM. Methods 316 cases with AMI were collected, including 114 cases combined with T2DM and 202 cases without DM in Hospital. Hs-CRP, GSP, Apo A and HDL-C were detected. Firstly, treatment outcome improved group compared with deteriorating group, secondly, AMI+ T2DM group compared with AMI without DM group. Results In deteriorating group, the patients's age and hs-CRP were significantly higher than those in improved group. Old age and high level of hs-CRP were independent risk factors of treatment outcome. The level of GSP, the level of HGB and the component of sex between AMI+T2DM group and AMI without DM group were significantly different. Among patients with AMI and T2DM,different level of GSP lead to different treatment out-come(P＜0. 05). Conclusion The higher age and the level of hs-CRP were,the worse the treatment outcome in AMI was, Apo A, HDL-C,FIB and HGB have no significant impact on the treatment outcome in AMI. Among cases with AMI and T2DM,the higher level of GSP was,the lower improvememt rate was.%目的 探讨高敏C反应蛋白(hs-CRP)、糖化血清蛋白(GSP)、载脂蛋白A(Apo A)、高密度脂蛋白胆固醇(HDL-C)与2型糖尿病(T2DM)合并急性心肌梗死(AMI)治疗转归的相关性.方法 收集住院治疗的AMI患者316例,分为两组,合并T2DM组114例,非糖尿病组202例,检测hs-CRP、GSP、Apo A、HDL-C等指标,先在治疗好转组与恶化组之间进行比较;再在糖尿病组与非糖尿病组之间进行比较.结果 与好转组相比,恶化组患者年龄较大,hs-CRP水平较高,年龄、hs-CRP是治疗转归的危险因素.合并T2DM组与非糖尿组比较,GSP、HGB、性别构成差异有统计学意义(P＜0.05).在合并T2DM组中,不同GSP水平治疗转归差异有统计学意义(P＜0.05).结论 年龄越大、hs-CRP越高,则AMI患者预后恶化的可能性越大,血清Apo A、HDL-C、FIB、HGB对其治疗转归无明显影响.在AMI合并T2DM患者中GSP水平高者较GSP水平低者预后差.