帕金森病患者血清炎症因子水平及其临床意义

摘要

目的：探讨帕金森病（PD）患者血清中主要炎症因子IL‐1β、IL‐6、肿瘤坏死因子α（TNF‐α）和干扰素γ（IFN‐γ）水平的变化及其与病程、疾病严重程度的相关性。方法采集56例PD患者及120例健康者（对照组）的血液样本，采用ELISA检测血清中的IL‐1β、IL‐6、TNF‐α和IFN‐γ的水平。结果PD患者血清IL‐1β、IL‐6及TNF‐α水平显著高于对照组（P＜0．01），血清IFN‐γ水平差异无统计学意义（P＝0．86）。PD患者血清炎症因子水平与病程、Hoen&Yahr分期、Schwab&England日常活动分级评分均无相关性（P＞0．05）。结论炎症参与了PD的病理过程，血清炎症因子与病程和疾病严重程度均无相关性。%Objective To compare the serum levels of interleukin(IL)‐1β,IL‐6 ,tumor necrosis factor alpha(TNF‐α) and inter‐feron gamma(IFN‐γ) in patients with Parkinson′s disease(PD) and healthy controls .To analyze the correlations of serum inflamma‐tory factors with disease duration and severity .Methods Peripheral blood samples were collected from 56 PD patients and 120 healthy controls .Serum levels of IL‐1β,IL‐6 ,TNF‐αand IFN‐γwere measured using highly sensitive enzyme linked immunosorbent assay(ELISA) kits .Results Serum levels of IL‐1β,IL‐6 ,TNF‐α were significantly higher in PD patients than in healthy controls (all P<0 .01) ,serum levels of IFN‐γ were not significantly different between PD patients and healthy controls (P=0 .86) .Serum levels of these inflammatory cytokines were not significantly correlated with the disease ,duration ,Hoen & Yahr ,Schwab & Eng‐land scores(P>0 .05) .Conclusion Our results indicate that serum inflammatory factors are altered in PD patients .However ,serum inflammatory factors were not correlated with disease duration and severity .