Objective To investigate the expression differences of β‐catenin ,Her‐2/Neu and ki‐67 in different pathological features of gastric cancer and their role in the occurrence ,progression ,invasion and metastasis of gastric cancer invasion and metas‐tasis .Methods The expression of β‐catenin ,ki‐67 and Her‐2/Neu in 150 gastric cancer tissue samples(observation group) and 70 normal gastric mucosal samples were detected by adopting the immunohistochemistry method ,and the relationship between the ex‐pression of β‐catenin ,ki‐67 and Her‐2/Neu with the pathological features of gastric cancer was analyzed .Results Theβ‐catenin ,ki‐67 and Her‐2/Neu positive rate in the observation group was significantly higher than that in the control group (χ2 =30 .51 ,63 .74 , 11 .38 ,P<0 .01);the differentiation degree affected the expression of β‐catenin ,ki‐67 and Her‐2/Neu expression (χ2 =15 .82 ,8 .61 , 8 .11 ,P<0 .01);the lymph node metastasis affected the expression of ki‐67 and β‐catenin (χ2 = 6 .26 ,P< 0 .05;χ2 = 7 .36 ,P<0 .01);the invasion depth affected the expression of β‐catenin and ki‐67(χ2 =11 .34 ,P<0 .01);TMN affected the expression of ki‐67 and Her‐2/Neu(χ2 = 10 .85 ,14 .24 ,P< 0 .01);the β‐catenin and ki‐67 expression showed positive correlation .Conclusion β‐catenin ,ki‐67 and Her‐2/Neu may reflect the proliferation ,invasion and metastasis situation of tumor cells and their detection con‐duces to the judgment of prognosis .%目的：探讨β‐连环蛋白（β‐catenin）、增殖细胞核抗原ki‐67和人表皮生长因子受体2（Her‐2）／Neu在不同胃癌病理特征中的表达差异及在胃癌发生、发展和侵袭、转移中的作用。方法分别采用免疫组化检测150份胃癌组织（观察组）和70份正常胃黏膜（经病理检测无癌变作为对照组）中β‐catenin、ki‐67及 Her‐2／Neu的表达，分析β‐catenin、ki‐67及 Her‐2／Neu与胃癌病理特征的关系。结果观察组患者β‐catenin、ki‐67、Her‐2／Neu阳性率明显高于对照组（χ2＝30．51、63．74、11．38，P＜0．01）；分化程度影响β‐catenin、ki‐67、Her‐2／Neu表达（χ2＝15．82、8．61、8．11，P＜0．01）；淋巴结转移影响β‐catenin、ki‐67表达（χ2＝6．26， P＜0．05；χ2＝7．36，P＜0．01）；侵润深度影响β‐catenin、ki‐67表达（均χ2＝11．34，P＜0．01）；TMN影响 ki‐67、Her‐2／Neu表达（χ2＝10．85、14．24，P＜0．01）；β‐catenin和ki‐67表达呈正相关。结论β‐catenin、ki‐67和Her‐2／Neu可反映肿瘤细胞增殖、侵袭和转移的情况，有助于对患者预后的判断。
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