血液透析对尿毒症患者Treg与Th17水平失衡的影响分析

摘要

目的 探讨维持性血液透析对尿毒症患者调节性T细胞(Treg)和辅助性T细胞(Th17)的影响.方法 选取2014年2月至2017年2月在该院治疗的尿毒症患者185例,其中行血液透析治疗患者102例为透析组,未行血液透析治疗患者83例为非透析组,同时选取健康志愿者100例作为对照组,检测各组Treg、Th17、白细胞介素(IL)-6、IL-10和IL-17水平.结果 对照组Treg、Th17、IL-6和IL-17水平明显低于非透析组和透析组(P＜0.05),而IL-10水平明显高于非透析组和透析组(P＜0.05).透析组Treg、Th17、IL-6和IL-17分别为(5.02±1.80)％、(20.16±7.04)％、(28.78±4.18)pg/mL和(40.38±9.03) pg/mL,明显低于非透析组(P＜0.05),而IL-10(18.52±2.19)pg/mL明显高于非透析组(P＜0.05).结论 尿毒症患者存在Treg与Th17水平失衡,而血液透析可帮助改善患者Treg与Th17水平失衡.%Objective To investigate the effect of maintenance hemodialysis on regulatory T cells (Treg) and helper T cells (Th17) in uremic patients.Methods One hundred and eighty-five patients with uremia from February 2014 to February 2017 in our hospital were selected,including 102 cases of hemodialysis as the dialysis group and 83 cases without conducting hemodialysis as the non-dialysis group.Contemporaneous 100 healthy volunteers were selected as the control group.The levels of Treg,Th17,interleukin-6 (IL-6),IL-10 and IL-17 were detected in each group.Results The levels of Treg,Th17,IL-6 and IL-17 in the control group were significantly lower than those in the non-dialysis group and dialysis group (P＜0.05),while the level of IL-10 was significantly higher than that in the non-dialysis group and dialysis group (P＜0.05);the levels of Treg,Th17,IL-6 and IL-17 in the dialysis group were (5.02±1.80)％,(20.16±7.04)％,(28.78± 4.18) pg/mL and (40.38±9.03) pg/mL,which were significantly lower than those in the non-dialysis group (P＜0.05),and the IL-10 level in the dialysis group was (18.52±2.19) pg/ml,which was significantly higher than that in the non-dialysis group (P＜0.05).Conclusion The imbalance of Treg and Th17 levels exist in uremic patients,and hemodialysis can help to improve the imbalance of Treg and Th17 levels.