目的 建立新型腹型肥胖实验动物模型.方法 30只小鼠随机分为空白对照组、模型组、食量控制组.空白对照组一次性注射生理盐水并自由饮食;模型组一次性注射氯丙嗪4 mg·kg-1并自由饮食;食量控制组一次性注射氯丙嗪4 mg·kg-1并控制食量同空白对照组,3组均喂饲基础饲料,共15 d.测定小鼠体重、Lee's指数、内脏脂肪湿重、血糖和血脂水平,病理切片观察脂肪组织形态学差异.结果 模型组、食量控制组小鼠均表现出内脏脂肪大量堆积,形成腹型肥胖,并出现GLU、TG、TC升高和HDL-C降低的糖脂代谢紊乱.结论 一次性注射氯丙嗪的小鼠具有与中老年人腹型肥胖相似的临床特征,可作为中老年腹型肥胖相关药物研究的筛选模型.%Aim To establish a new model of obese mice. Methods 30 mice were randomly divided into control group, model group, diet controlling group. The mice of control group were given one-time injection of normal saline and free diet. Those of model group were given one-time injection of chlor-promazine and free diet. Those of diet controlling group were given one-time injection of chlorpromazine with the same food intake as the control group. Three groups were all fed with standard diet, a total of 15d. The indices of experiments were body weight, Lee' s index, wet weight of visceral adipose tissue and testicular, blood lipid and glucose level. And the difference in morphology of adipose tissue was observed. Results Model group and diet controlling group both showed a large accumulation of visceral adipose, and formed abdominal obesity. GLU, TG and TC significantly increased( P < 0. 01 ) but HDL-C de-creased( P < 0. 05 ). Conclusion One-time injection of chlorpromazine in mice which has the similar clinical features with elderly abdominal obesity can be used as screening model of elderly abdominal obesity related drug.
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