丹参水溶性成分影响骨代谢的机制研究进展

摘要

丹参是一种治疗心血管疾病的传统中药。近年来，越来越多的研究表明，以丹参素和丹参酚酸B为代表的丹参水溶性酚酸类成分具有调节骨代谢的作用，涉及Wnt／β-cate-nin、ERK、BMP、OPG／RANKL／RANK以及FoxO介导的氧化应激等多种信号通路调节机制。该文主要综述丹参水溶性酚酸类成分的前述作用及分子机制，为进一步研究与开发抗骨质疏松药物提供依据。%Salvia miltiorrhiza is a traditional Chinese medicine for the treatment of cardiovascular diseases .Recently, increasing evidence demonstrates that the water-soluble compounds isolated from Salvia miltiorrhiza,including tanshinol and salvianolic acid B, exert a regulatory influence on bone metabolism .The under-lying mechanism of these compounds involves various pathways , such as Wnt/β-catenin, ERK, BMP, OPG/RANKL/RANK and FoxO mediated oxidative stress pathway .This paper reviews pre-vious effects and mechanism of polyphenolic acids in Salvia milt-iorrhiza , which may provide the base for the research and devel-opment of the new agents to treat osteoporosis .