丹参及其有效成分对骨代谢影响的实验研究进展

摘要

Salvia miltiorrhiza is famous traditional Chinese medicine which can promote blood circulation to remove blood stasis. Recent study reveals that salvia miltiorrhiza and its effective components can accelerate osteogenesis, treat osteoporosis, and influence bone metabolism. This article reviews the latest national and international literatures concerning salvia miltiorrhiza and its effective components, including tanshinone IIA, Denshensu, salvianolic acid B, and protocatechualdehyde, which can treat osteoporosis, promote bone formation, promote differentiate of osteoblasts and chondrocytes by mesenchymal stem cells, promote fracture healing, promote osteoblast and chondrocyte proliferation, inhibit osteoclasts, and alleviate metabolic disorder of mineral element in bone tissue. Study of the mechanism of salvia miltiorrhiza action on bone metabolism may benefit in exploration the therapeutic action of salvia miltiorrhiza for osteoporosis, which can promote the modernization of traditional Chinese medicine.%丹参是经典的活血化瘀中药，近些年来研究发现丹参及其有效成分还有促进骨形成、抗骨质疏松，或影响骨代谢的作用，本文回顾了国内外最新的文献，主要针对丹参以及其有效成分丹参酮IIA、丹参素、丹酚酸B和儿茶醛等，能抗骨质疏松、促进骨形成、促进间充质干细胞向成骨细胞及软骨细胞分化、有促进骨折愈合、促进成骨细胞和软骨细胞增殖、抑制破骨细胞和抗骨组织无机元素代谢紊乱的作用作综述。研究和阐明丹参影响骨代谢的机制，有利于发掘丹参的的抗骨质疏松治疗作用，为骨质疏松的治疗提供新方法，并推动中药现代化。