降钙素原、超敏C反应蛋白及白细胞联合检测在新生儿败血症早期诊断中的应用价值

摘要

目的：探讨降钙素原（PCT）、超敏 C 反应蛋白（hs-CRP）及白细胞（WBC）联合检测在新生儿败血症早期诊断中的应用。方法选取2013年1月至2016年1月确诊新生儿败血症患儿68例为观察组，同期健康新生儿68例为对照组，采用酶联荧光分析技术测定 PCT，免疫比浊法测定 hs-CRP，Sysmex 800血液分析仪分析 WBC。结果治疗前观察组 PCT、hs-CRP 及 WBC 值明显高于对照组，差异有统计学意义（P ＜0.05），治疗后观察组 PCT、hs-CRP 及 WBC 值明显降低，与治疗前比较差异有统计学意义（P ＜0.05）；PCT、hs-CRP 及 WBC 三项联合检测用于诊断的特异性、阳性预测值及阴性预测值均高于任意两项联合检测。结论PCT、hs-CRP 及 WBC 联合检测可用于新生儿败血症早期诊断，有助于提高诊断准确率。%Objective To study the application of combined detection of PCT,hs-CRP and WBC in the early diagnosis of neonatal sepsis.Methods A total of 68 neonates diagnosed with sepsis from Jan.2013 to Jan.2016 were chosen as the observation group,and 68 healthy neonates in the same period were included as the control group.Enzyme-linked fluorescence analysis was used to detect PCT,immuno turbidimetry was used to detect hs-CRP and Sysmex 800 blood analyzer was used to analyze WBC.Results The value of PCT,hs-CRP and WBC was remarkably higher in the observation group than in the control group before treatment(P <0.05),but after treatment,these values significantly decreased in observation group,and there was statistical difference compared with those before treatment(P <0.05).The combined detection of PCT,hs-CRP and WBC was higher in specificity of diagnosis,positive prediction value and negative prediction value when compared with the combined detection of any two items.Conclusion The combined detection of PCT,hs-CRP and WBC can be used in the early diagnosis of neonatal sepsis,which helps to improve the diagnosis accuracy.