番荔枝内生菌拟茎点霉B27中分离到的一个新十元大环内酯

摘要

目的:研究番荔枝内生真菌拟茎点霉B27的化学成分.方法:通过色谱层析柱对提取物进行分离纯化.并通过波谱解析(一维、二维的核磁共振谱和质谱)确定化合物的结构.结果:分离纯化得到5个化合物,鉴定为十元大环内酯phomolideC(1),1-甲基-8-羟基-9,10-蒽醌(2),1,8-双羟基-9,10-蒽醌(3),cytosporoneC(4)和Altiloxin A(5).结论:化合物1是新化合物:化合物1-5首次从拟茎点霉属菌株中分离得到.%AIM: To study the chemical constituents of Phomopsis sp.B27,an endophyfic fungal strain ofAnnona squamosa L.METHODS: The extract was isolated and purified by column chromatography.The structures of chemical components were determined by spectroscopic analyses including 1D-,2D-NMR and MS data.RESULTS: Five compounds were isolated and determined as a ten-membered iactone,namely phomolide C (1),1-methoxy-8-hydroxy-9,10-anthraquinone (2),1,8-dihydroxy-9,10-anthra- quinone (1,8-DHA) (3),cytosporone C (4) and altiloxin A (5).CONCLUSION: Compound 1 is a new ten-membered lactone; and compounds 1-5 were isolated from the genus Phomopsis for the first time.