目的:通过在1.5T、3.0T磁共振机器上分别使用低剂量及常规剂量对比剂行下肢动脉三维对比增强磁共振血管成像(3D contrast enhanced MR angiography,3D CE-MRA)的对比研究,探讨下肢动脉性疾病安全、有效的检查方法,为准确评估下肢动脉性病变提供可靠依据.方法:选取临床怀疑下肢动脉狭窄或闭塞病变者31例,其中1例患者因为病变,右小腿已经截肢,行下肢动脉3D CE-MRA检查.18例在1.5T MR机器上以常规剂量(38 ml)注射对比剂,13例在3.0T MR机器上以低剂量(15 ml)注射对比剂,对比分析二者评估图像质量的差异.结果:所有行3DCE-MRA检查者无造影剂过敏反应发生,其中1例因左侧小腿不自主轻微抖动造成左侧胫腓段图像运动伪影.在1.5T MR机器上使用常规剂量对比剂与在3.0T MR机器上使用低剂量对比剂相比,后者的小腿段图像质量优率呈现出高于前者趋势,各段血管除胭动脉段外图像质量之间的差异均无明显统计学意义(P＞0.05).结论:3D CE-MRA是下肢动脉病变有效、安全的检查方法,尤其是在3.0T MR机器上使用低剂量对比剂注射法可以为临床诊断和治疗提供更为安全可靠的依据.%Objective To explore a safe and effective imaging method by the application of 3D contrast-enhanced MR Angiography (3D CE-MRA) with low-or conventional-dose contrast agent to the examination of lower extremity arterial disease.Methods Totally 31 patients suspected with lower extremity arterial stenosis or occlusion underwent 3D CE-MRA examination including one patient had right leg cut due to the disease,of whom,18 ones had conventional-dose contrast agent (38 ml) injected in 1.5T MR machine and 13 ones had low-dose agent (15 ml) injected in 3.0T MR machine.Quality evaluation was carried out for the images by different doses of agents.Results All the patients had no agent allergy occurred,and one patient had left tibia-fibula motion artifact due to involuntary movement.3.0T MR machine with low-dose agent behaved better than 1.ST MR machine with conventional-dose agent in leg imaging,while there were no significant differences between the quality of the images except that of popliteal artery (P＞0.05).Conclusion 3D CE-MRA is an effective and safe method in detecting lower extremity artery disease,and 3.0T MR machine with low-dose agent lays a foundation for clinical diagnosis and treatment.
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