布鲁氏菌的致病机制与细胞免疫机制研究进展

摘要

Brucellosis is a serious zoonotic infectious disease caused by Brucella spp. CBra) infection. The disease infects people who contact with sick animals or contaminated animal products. Brit is a facultative intracellular bacterium and its target cells are macrophages and placental trophoblast cells, but Bru can grow and reproduce in dendritic cells (DCs) also. The lipopolysaccharide (LPS) and outer membrane protein are the most important antigens on the cell surface. Brucellosis is a Thl-type cellular immune response mainly and DCs play an important role in the anti-Bra infection. This paper analyzed the molecular bionomics of Bru major antigens, and reviewed the Bru pathogenic mechanism and the progress of anti-Bru immune response that macrophages and DCs involved.%目的 布鲁氏菌病是由布鲁氏菌( brucella species,Bru)感染引起的一种严重的人兽共患性传染病,人在接触患病动物或被污染的动物产品后即可发病.Bru是一种兼性细胞内感染细菌,菌体表面最主要的抗原包括脂多糖(LPS)和外膜蛋白等,其感染的靶细胞主要是巨噬细胞与胎盘滋养层细胞,但也可在树突状细胞(dendritic cell,DCs)中生长繁殖.该病主要以Th1型细胞免疫应答为主,由DCs诱导的细胞免疫应答在机体抗Bru感染中发挥着重要作用.本文在分析Bru主要抗原分子生物学特性的基础上,就Bru的致病机制及巨噬细胞与DCs参与的机体抗Bru过程的研究进展作一综述.