Etiopathogenic Mechanisms of Bronchoconstriction in Byssinosis-A Review

摘要

Studies of etiopathogenic mechanisms of Bronchoconstriction in byssinosis indicate the possible involvement of histamine, 5-HT, platelet-activating factor and metabolites of arachidonic acid as mediators of bronchoconstriction. These substances might be released by a variety of lung and/or recruited cells to induce constriction of respiratory airways characteristic of the acute bronchoconstriction by more than one mechanism and that a number of factors, both endogenous and exogenous, influence the increased bronchomotor response to cotton dust inhalation in given textile worker. (Reprints)