血管新生在肝泡球蚴浸润性生长中的作用

摘要

Alveolar echinococcosis (AE) is a potentially fatal zoonosis caused by Echinococcus multilocularis (E .m) , primary located in the liver and showed malignant invasion .AE can develop to the lungs and brain metastases .Operation treat-ment and medication therapeutic efficacy show poor effect .The mechanism of AE invasive growth and metastasis is unclear . Angiogenesis is a highly regulated behavior in normal tissues .Abnormal angiogenesis is one of the key signs of malignant tumor ,and VEGF is one of the key mediators of angiogenesis .Numerous studies have shown that VEGF and CD34 plays an important role in the formation of tumor angiogenesis and invasive growth process .This article discussed the role of angiogene-sis in AE aggressive ,aimed to provide a new way for the clinic conservative treatment for patients with advanced stage ,preven-ting recurrence after operation ,and adjunctive therapy of operation and drug .%泡球蚴病是对人体危害极大地人兽共患寄生虫病，原发于肝脏，呈恶性浸润性生长，可继发肺、脑转移，手术及药物治疗效果差，其浸润性生长和转移的机制尚不明确，血管新生在正常组织中是被高度管制的行为，异常情况下的血管新生是恶性肿瘤的关键标志之一。VEGF是血管新生中关键的介质。研究显示VEGF和CD34在肿瘤新生血管形成及侵袭性生长过程中起着重要作用。本文初步探讨血管生成在泡球蚴侵袭性中的作用，为临床上泡球蚴病晚期患者的保守治疗、以及手术、药物的辅助治疗提供一个新途径。